Incorporation of Biologic Response Variance Modeling Into the Clinic: Limiting Risk of Brachial Plexopathy and Other Late Effects of Breast Cancer Proton Beam Therapy.

As expected, owing to biologic range extension, the median IMN CTV D95% and heart Dmax were significantly greater for the MCBD than for the MCPD (RBE 1.1) plans, although mean heart dose did not reach statistical significance ( Table 4 ).

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