Barely Significant
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A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure.

Invest Ophthalmol Vis Sci · 2020 · PMC7735951 · PMID 33315051

Europe PMCDOI
1
hedged sentence
0.0553
closest p · 1.1× alpha
0.0553
boldest claim

The sentences

did not reach statistical significanceP = 0.0553so close (0.05 < p ≤ 0.1)
A mixed-effect model, repeated measure analysis showed a statistically significant 1.26 mm Hg mean reduction in IOP in the AKB-9778 BID group compared to placebo ( P < 0.001; 95% CI = ‒0.62 to ‒1.90), whereas the 0.63 mm Hg reduction in the AKB-9778 QD group compared to placebo did not reach statistical significance ( P = 0.0553, 95% CI = 0.01 to ‒1.27).

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