Differential Effects of Acute Treatment With Antipsychotic Drugs on Peripheral Catecholamines.

Front Psychiatry · 2020 · PMC7735989 · PMID 33335492

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0570

boldest claim

The sentences

highly significantp < 0.001actually significant

However, the high dose of clozapine evinced a large, highly significant increase in norepinephrine levels compared to both the controls and the low dose of clozapine at all time points after treatment ( p < 0.001).

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a strong trendp = 0.057so close (0.05 < p ≤ 0.1)

Follow-up post-hoc tests showed that while low dose risperidone and vehicle-treated rats did not differ at any time point in dopamine levels, the levels were significantly higher in the high dose group compared to the low dose group at 30 and 60 mins ( p < 0.05) ( Figure 4A ), with a strong trend vs. controls ( p = 0.057 and 0.072, respectively).

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