As expected, a positive trend of correlation for genes driving inflammation, innate immunity and invasion processes, mostly up-regulated in the BRAF -mutated pathway, was shown, whereas the typically down-regulated CDX2 and Wnt target genes, displayed a negative trend [ 6 , 11 , 38 , 39 ].
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BRAF<sup>V600E</sup> mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies.
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