Simultaneous two‐line cytopenia and pancytopenia were numerically increased among subjects randomized to LD‐MTX, although these events did not reach statistical significance, as they were uncommon in both arms.
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Adverse Effects of Low-Dose Methotrexate in a Randomized Double-Blind Placebo-Controlled Trial: Adjudicated Hematologic and Skin Cancer Outcomes in the Cardiovascular Inflammation Reduction Trial.
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