Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis.

Serum anti-dsDNA antibody levels were lower in the hUC-MSCs-treated group, but did not reach statistical significance (Figure 1 E).

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There was a significant difference between two groups to the proportion of CD27-CD28+ cells, and an increasing trend toward CD27-CD28- cells in hUC-MSCs group ( Supplementary information , Figure S2 ).

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