Effects of Omecamtiv Mecarbil on Symptoms and Health-Related Quality of Life in Patients With Chronic Heart Failure: Results From the COSMIC-HF Study.

Circ Heart Fail · 2020 · PMC7742205 · PMID 33176437

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did not reach statistical significanceno p-value reported

Given the smaller sample size and shorter duration of treatment (20 weeks), and the violation of normality (changes from the baseline of PLS), the CIs around the effect estimates on HRQL are broad in comparison to those from larger phase 3 studies of other therapies, and most of the observed differences in KCCQ did not reach statistical significance.

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