Exploring the utility of RDoC in differentiating effectiveness amongst antidepressants: A systematic review using proposed psychometrics as the unit of analysis for the Negative Valence Systems domain.

However, when the sample comprise those with MDD where comorbid mild neurocognitive disorder with MMSE score > = 23 or personality disorders were not excluded, the reduction from 1.5 (SD = 0.67) to 1.2 (SD = 1.13) did not reach statistical significance (p value not stated) [ 27 ].

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