Opportunistic screening and survival prediction of digestive cancers by the combination of blood <i>mSEPT9</i> with protein markers.

Interestingly, when survival data was stratified by cancer stage ( Supplemental Figure 2 ), significant or almost significant differences were detected between mSEPT9 -positive and -negative subjects in stage III of CRC ( p = 0.15), GC ( p = 0.047), EC ( p = 0.071), and HCC ( p = 0.265); and in stage IV of CRC ( p = 0.052), but not in stage I and stage II.

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This was more obvious for GC, EC, and HCC than for CRC, in which there was a clear trend for increased sensitivity with increasing age ( Figure 4 ; lower row).

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