Network preservation reveals shared and unique biological processes associated with chronic alcohol abuse in NAc and PFC.

The NAc miRNA data revealed 430 nominally significant loci, which clustered in 5 modules ranging from 18 (NAcmi green ) to 259 (NAcmi turquoise ) loci in size, of which, at Bonferroni adjusted p ≤0.05, three miRNA modules remained significantly correlated to AD (NAcmi yellow , NAcmi brown , and NAcmi turquiose ).

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We selected highly significant eQTLs ( FCGR3A (Fc fragment of IgG receptor IIIa): rs12087446 and DNALI1 (dynein axonemal light intermediate chain 1): rs12119598 ) based on FCGR3A and DNALI1 ’s role as network hubs to highlight the interaction between AD case status and eQTL while also demonstrating brain region-specific eQTL variation.

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