Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis.

However, even in the majority of sites that did not reach statistical significance, CA-MSCs in general demonstrated a decrease in accessibility compared to normal MSCs after normalizing for library size ( Figure 3B ), consistent with the observed widespread gain of DNA methylation in CA-MSCs.

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