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Characterization of cachexia in the human fibrosarcoma HT-1080 mouse tumour model.

J Cachexia Sarcopenia Muscle · 2020 · PMC7749621 · PMID 32924335

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In the gastrocnemius and tibialis anterior skeletal muscles, expression of genes related to E3 ubiquitin ligase induction ( MuRF1 , Atrogin‐1 , Foxo1 ) and autophagy ( Bnip3 ) in HT‐1080 tumour‐bearing mice compared with NTB tended to increase, but most did not reach statistical significance despite the large sample size ( Table 2 ).

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