Although the high group was marginally significant for improved OS (hazard ratio (HR)=0.559, P=0.066), it was statistically significant for improved DFS (HR=0.398, P=0.011), and locoregional recurrence-free survival (HR=0.165, P=0.001) with acceptable complications.
However, most studies showed a trend toward survival benefits in the CRT+S group, except for one study. 38 Only one study showed significant survival benefits in the CRT+S group. 32 Controversies of Clinical Issues Indications In the NCCN guidelines, surveillance is recommended for clinical T1-2N0M0 EC patients with negative margins (R0 resection) after radical surgery regardless of the pathological stage (p Any T, Any N) and CRT+S is recommended for patients with resectable clinical T3-4N0M0 or T1-4N+M0 diseases.