PD-L1 Is a Tumor Suppressor in Aggressive Endometrial Cancer Cells and Its Expression Is Regulated by miR-216a and lncRNA MEG3.

Front Cell Dev Biol · 2020 · PMC7755603 · PMID 33363153

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0730

boldest claim

The sentences

did not reach statistical significanceP > 0.05actually significant

A trend of higher PD-L1 expression was noted in patients younger than 50 years, and in patients with low-grade tumors (grade 1/2), early stage tumors (stage I), smaller tumor size (tumor diameter ≤3 cm), or superficial myometrial invasion (≤1/2), although this did not reach statistical significance ( P > 0.05) ( Supplementary Figure 2 ).

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marginally significantP = 0.073so close (0.05 < p ≤ 0.1)

There was a marginally significant relationship between increased PD-L1 expression and improved overall survival in patients at histological grade 2 ( P = 0.073) ( Supplementary Figure 1 ).

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