From the target proteins shown in Figure 2 , RASD1 was selected for further validation since the differential expression between relapse, and controls almost reached significance in the microarray ( p -value = 0.058, Figure 1 and Figure 2 ).
While RASD1 expression levels were lower in relapse patients than in controls, which reached borderline significance with a p -value of 0.058, no difference could be detected for Sec23A ( p -value = 0.628) and ER-α ( p -values between 0.546 and 0.902; Figure 2 ).The microarray data were deposited in the NCBI Gene Expression Omnibus.