Recurrent Nasopharyngeal Cancer: Critical Review of Local Treatment Options Including Recommendations during the COVID-19 Pandemic.

With the use of hyperfractionation, the median local failure-free survival showed a trend in favor of hyperfractionated re-IMRT compared to standard fractionation (28.2 vs. 16.6 months, p = 0.164) but OS was not significantly different (34.8 vs. 35.5 months, p = 0.603) [ 87 ].

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Late morbidity of re-irradiation in the base of the skull region may be significant, and a high level of clinical and radiotherapy planning expertise is required.

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