Psychiatric and Psychological Interventions for Depression in Patients With Heart Disease: A Scoping Review.

25 Pizzi and associates observed mixed but largely negative effects of SSRIs on cardiac markers in the UPBEAT study, with nearly significant increases in heart rate variability with sertraline compared with exercise or placebo in the 3‐arm trial, but no change in other markers of inflammation, endothelial and platelet function, or baroreflex sensitivity. 29 Three studies have examined longer‐term effects on major cardiac events.

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