Direct Oral Anticoagulants in Patients With Inherited Thrombophilia and Venous Thromboembolism: A Prospective Cohort Study.

J Am Heart Assoc · 2020 · PMC7763770 · PMID 33222589

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showed a trendno p-value reported

The post hoc analysis showed a trend of fewer major bleeding and CRNMB in patients with thrombophilia treated with dabigatran versus VKAs (HR, 0.51; 95% CI, 0.05–5.59 and HR, 0.48; 95% CI, 0.19–1.19). 16 We observed a significantly higher number of CRNMB in patients with thrombophilia treated with DOACs versus controls—the most reported were genitourinary hemorrhages (menometrorrhagia and macrohematuria).

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