The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction.

Cancers (Basel) · 2020 · PMC7766767 · PMID 33348673

Europe PMC DOI

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closest p · 1.6× alpha

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a strong trendp = 0.08so close (0.05 < p ≤ 0.1)

However, when we evaluated MMP-9 and MMP-2 activity in EDL homogenate (EDL muscles have a similar fiber type composition to TA muscles) via gelatin zymography, we found a strong trend for IRI+BGP treatment to increase MMP-9 activity relative to VEH ( p = 0.08; Figure 4 J,N) whilst also significantly reducing MMP-2 activity compared to VEH and IRI treatments ( p < 0.05; Figure 4 K,N).

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