The Histamine 3 Receptor Is Expressed in the Heart and Its Activation Opposes Adverse Cardiac Remodeling in the Angiotensin II Mouse Model.

While, generally speaking, there were no significant differences in the echocardiography parameters assessed ( Figure 3 A–I and Figure S7 ), there was a strong trend for LVPWd to be increased in Ang II ( p = 0.07 vs. saline) and high-dose Ang II + A331440 groups ( p = 0.06 vs. saline, Figure 3 C).

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