Topical exposure to triclosan inhibits Th1 immune responses and reduces T cells responding to influenza infection in mice.

As the changes in the remainder of cytokines produced by T cells did not reach statistical significance and occurred in both Th1 (IFN-γ, IL-12P70) and Th2 (IL-4, IL-5, and IL-13) associated cytokines, we believe this is likely reflective of the numerical reduction in infiltrating leukocytes including CD4+ and CD8+ T cells rather than a functional defect in the Th1 cell population.

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While there was an overall trend in reduced expression of a number of cytokines in TCS exposed infected mice compared the VC exposed infected mine, a significant decrease in only BALF IL-6 was observed in the TCS/PR8 mice compared to the VC/PR8 mice (230.9 ± 26.67 vs 133.3 ± 31.52 pg/ml).

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