nominally significantp < 0.0001
Given this lack of statistical significance in hierarchical testing, adjusted mean changes from baseline in total lesion volume on T2-weighted (T2W) images at 12 months and 24 months in the siponimod group were considered nominally significant versus placebo (both timepoints p < 0.0001) (Table 1 ), with the adjusted average mean increase from baseline over both timepoints lower in the siponimod than placebo group (183.9 vs 879.2 mm 3 ; nominal p < 0.0001) [ 38 ].