Case Report: Efficacy of Reduced Doses of Asfotase Alfa Replacement Therapy in an Infant With Hypophosphatasia Who Lacked Severe Clinical Symptoms.

Additionally, in a study of adults and adolescents with pediatric-onset HPP, AA therapy at lower doses (2.1–3.5 mg/kg/week) led to normalization of circulating PLP and PPi levels, as well as significant improvement in functional assessments such as the 6-Minute Walk Test; however, the reduction in PPi did not reach statistical significance.

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