Fanconi anemia A protein participates in nucleolar homeostasis maintenance and ribosome biogenesis.

Depletion of FANCA or FANCD2 led to a slightly significant ( P < 0.05) increased frequency of cells with nucleoli presenting γ-H2AX foci, a widely accepted readout of the presence of DNA breaks, in association with the induction of rDNA rearrangements as determined by polymerase chain reaction (PCR) analysis ( Fig. 2, C and D ).

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