Interestingly, Hfe LysMCre mutant mice showed a trend towards a higher degree of induction of granulocyte colony-stimulating factor, interferon γ, interleukin (IL)-1b, IL-17α ( Online Supplementary Figure S2C ) and reduced induction of eotaxin, IL2, IL4, IL5, IL6, IL10, IL13, macrophage inflammatory protein 1α, and tumor necrosis factor α (TNF-α) mediators compared to control mice ( Online Supplementary Figure S2D ), raising the question of whether differential expression of these immune mediators may explain the remarkably higher tolerance of aged Hfe LysMCre mice to LPS-induced shock.
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Macrophage-HFE controls iron metabolism and immune responses in aged mice.
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