Molecular mechanisms of osteogenesis and antibacterial activity of Cu-bearing Ti alloy in a bone defect model with infection <i>in vivo</i>.

aureus in the Ti6Al4V-6.5wt%Cu alloy showed a trend of decreasing ( Fig. 3 B), indicating Ti6Al4V-6.5wt%Cu alloy inhibited the activity of S. aureus at the early stage of bacterial adhesion and accelerated its aging and death at 6–8 ​h.

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aureus on Ti6Al4V alloy showed an increasing trend but the percentage of viable bacteria remained at 55%–90% after co-culture for 12 ​h [ Fig. 3A(d-1) and (d-2 )].

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