Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.

In animals given intraperitoneal (IP) saline injections immediately after their final RMS episode and sacrificed 90 min later, hippocampal IL-1β protein showed a trend increase in RMS animals ( Saavedra et al., 2017 ); here, because both RMS and control animals received IP injections, both groups experienced a brief stressor which may have reduced the statistical power to detect an RMS-induced effect on cytokine expression.

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