Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting.

Notably, NK-92 cells alone showed medium basal secretion of granzyme B, MIP-1b and perforin which was further augmented after AdCAR activation (2.2-fold, 1.5-fold and 1.3-fold, respectively) but did not reach statistical significance ( Figure 3h ).

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