Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production.

Although Stat2 Δ-DC pDCs showed less upregulation, it did not reach statistical significance ( figure 3f,i ), possibly because CD11c+Cre is expressed less in pDCs. 35 Hence, our results corroborate our previous study with Stat2KO mice 12 and show conclusively that intrinsic STAT2 in cDCs is critical for their responses to systemic TLR activation mediated by autocrine/paracrine IFN-I.

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