MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies.

Despite these trends, the differences measured between the vaccination groups did not reach statistical significance.

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Trends for a vaccine-induced increase in the frequency of cytokine-producing γδ T-cell populations were apparent in both the BCG and MTBVAC-vaccinated groups; however, these responses failed to reach significance above pre-vaccination levels (Supplementary Figs 6 and 7 ).

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