Effect of tofogliflozin on arterial stiffness in patients with type 2 diabetes: prespecified sub-analysis of the prospective, randomized, open-label, parallel-group comparative UTOPIA trial.

In the subgroup with the reduction in SBP during the observation period (tofogliflozin; n = 37, conventional treatment [n = 29], similar results were observed; however, they did not reach statistical significance (− 108.9 [− 260.2, 42.3], p = 0.15; − 99.1 [− 243.6, 45.4], p = 0.18; − 104.0 [− 246.9, 38.9], p = 0.15, respectively).

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