Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model.

Although reduced error times in step-through and increased step-through latency were observed in PLX3397 and rotenone cotreated mice compared with rotenone alone group, the difference did not reach statistical significance (Fig. 4 i).

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We did not find a significant difference in escape latency and traveled distance between 0.75 mg/kg rotenone-treated mice and vehicle controls, although an increasing trend was observed (Fig. 1 b).

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