showed a trendp = 0.03
Gene-gene interaction analyses The cohort from Rio de Janeiro showed a trend toward statistical evidence of interaction between TGFA rs1523305 and IRF6 rs642961 (p = 0.03, OR = 1.77) and between IRF6 rs2073487 and TGFA rs2902345 (p = 0.04, OR = 1.60).