Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia.

5-HT showed a trend to decrease in LID animals, especially in cortical regions, hippocampus, hypothalamus, and thalamus, indicated by the blue color on the heatmap ( Fig. 2B ); the difference was, however, not significant.

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The LID animals did not significantly differ from MPTP and non-LID groups, although there was a nonsignificant trend of increased DA in striatal structures ( Fig. 1C ), which may have arisen from high variance of DA levels in the LID group and the relatively small number of animals.

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