Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia.

All RUPP rats had an increase in percent reabsorptions and decrease in percent survival, despite the IL-2 dose administered ( p < 0.05) (Table 1 ), with RUPP + MD ( p = 0.43) and RUPP + HD IL-2 ( p = 0.33) increasing fetal death to a much greater degree than RUPP alone; however, this did not quite reach statistical significance.

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However, when we calculated fetal survivability, we found it to be even lower with basiliximab than with placental ischemia alone; however, this did not reach statistical significance.

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