Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model.

The levels of IL-6, NF-κB, iNOS, and NGAL were significantly altered or showed a trend towards being altered by chronic noise and APP/PS1 overexpression (Fig. 5 a–d, ANOVA output: IL-6: exposure F (1,18) = 24.27, P = 0.0001, genotype F (1,18) = 0.5591, P = 0.4643, interaction F (1,18) = 0.005064, P = 0.9441, post hoc WT CON vs WT NOISE P = 0.0080 , WT CON vs APP/PS1 CON P = 0.9629 ,

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