Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes.

PLoS Pathog · 2020 · PMC7793277 · PMID 33370382

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showed a trendno p-value reported

Correspondingly, these SP-swapped viruses showed a trend of or a significant increase in V2i mAb resistance vs WT: the cumulative neutralization AUC values decreased by 87 and 188 for 293T-derived CMU06-398F1 and CMU06-271.1, respectively, and by 125 for PBMC-derived CMU06-271.1.

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