Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity.

Int J Mol Sci · 2020 · PMC7795908 · PMID 33374803

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did not reach statistical significanceno p-value reported

A trend for delay was observed for acrophase, whereas amplitude seemed slightly decreased in the mouse islet treated with IL-1β, although these trends did not reach statistical significance ( Figure 1 C).

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