Repurposing of Biologic and Targeted Synthetic Anti-Rheumatic Drugs in COVID-19 and Hyper-Inflammation: A Comprehensive Review of Available and Emerging Evidence at the Peak of the Pandemic.

A separate trial evaluating the efficacy of sarilumab (administered at the dosage of 200 or 400 mg) in 420 critical patients also suggested a positive trend without reaching statistical significance ( Regeneron Pharmaceuticals, Inc., 2020 ).

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There was a favorable trend of clinical improvement and mortality in patients on mechanical ventilation, but also an unfavorable trend in non-mechanically ventilated subjects ( Sanofi, 2020 ).

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