Pharmacological and non-pharmacological therapeutic strategies in difficult-to-treat rheumatoid arthritis: a systematic literature review informing the EULAR recommendations for the management of difficult-to-treat rheumatoid arthritis.

RMD Open · 2021 · PMC7798678 · PMID 33419871

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did not reach statistical significanceno p-value reported

20 In an observational study (high RoB) in patients with HCV undergoing treatment with TNFi, liver disease developed more frequently compared with patients without HCV (development of liver injury within 1 year: 10% vs 1.23%, p=0.099), 34 a difference that did not reach statistical significance in this relatively small sample size (n=101).

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