Dual Angiotensin Receptor-Neprilysin Inhibition With Sacubitril/Valsartan Attenuates Systolic Dysfunction in Experimental Doxorubicin-Induced Cardiotoxicity.

Myocyte cross-sectional area was reduced in all DOX-treated groups (DOX: 358.3 ± 15.4 μm 2 ; DOX + Val: 341.6 ± 9.2 μm 2 ; p < 0.05; DOX + Sac/Val: 310.5 ± 12.5 μm 2 ; p < 0.05) when compared with time-matched control animals (393.5 ± 16.7 μm 2 ) at 4 weeks, although this reduction did not reach statistical significance in the DOX-alone group (p > 0.05) ( Figures 7A and 7B ).

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