A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.

Nat Commun · 2021 · PMC7804859 · PMID 33436646

Europe PMC DOI

hedged sentence

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

did not reach statistical significancep = 0.063so close (0.05 < p ≤ 0.1)

injection of LIT01-196 (900 nmol/kg) in alert Sprague–Dawley rats, mean arterial blood pressure (MABP) decreased slightly 3 h after administration, and this change did not reach statistical significance (baseline MABP, 106 ± 2 mmHg, MABP 3 h after LIT01-196 administration, 94 ± 2 mmHg, p = 0.063, n = 5).

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