Inducible Deletion of YAP and TAZ in Adult Mouse Smooth Muscle Causes Rapid and Lethal Colonic Pseudo-Obstruction.

Although the expression of YAP/TAZ in human disease was not investigated herein, we report highly significant positive correlations of YAP/TAZ/TEAD with muscarinic receptors and regulators of smooth muscle–specific gene expression throughout the human GI tract.

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Furthermore, the muscarinic M 3 receptor ( Chrm3 ) was reduced in bladder (fold change in KO vs Ctrl bladder, 0.41; P adj = 8.82 × 10 -7 ), while the change did not reach statistical significance using the adjusted P value in the colon (fold change in KO vs Ctrl colon, 0.33; P adj = .15).

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