A decrease in PPD specific CD4 T cell CD38 and HLA-DR expression in pulmonary tuberculosis patients after 8 weeks of therapy correlates with successful anti-tuberculosis treatment.

It was found that the average proportion of the PPD specific CD4 T cells was higher in the before treatment group compared to the treatment group, but it did not reach statistical significance (see Table 3 ).

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This was due to a highly significant decrease in the PPD specific T cells positive CD38+ HLA-DR+ ( Fig. 2 ), and to some extent, though not statistically significant, a decrease in those CD38-HLA-DR+.

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