Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model.

However, there was an increasing trend in 6xTg compared to 5xFAD (cortex, 12.24 ± 2.3; hippocampus, 14.66 ± 4.13), but there was no significant difference (Fig. 4 B,C).

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There was a tendency toward an increase in the cortex of 4-month-old 6xTg (19.67 ± 5.01) mice compared to JNPL3 (9.25 ± 3.07, ns), which did not reach statistical significance (Fig. 3 B).

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