Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses.

4 g-h), although this did not reach statistical significance.

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While there have been no previous studies comparing TNF-α secretion in DF from patients with or without diabetes, we hypothesised that there may be significant differences in the secretion and/or response to TNF-α by DF derived from T2DM skin that may impact on wound healing.

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