In the cross-sectional population, we noted a highly significant correlation between MTR values of different tissue classes (Fig. 4 ).
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Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients.
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Similarly, the association of individual risk loci with MTR and volumetric measures did not reveal more nominally significant associations than expected by chance [non-HLA: 4.51% (60/1330); HLA 2.7% (6/220)] (Supplementary Table S4 – S5 ).