Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study.

First, our small sample size likely limited our ability to detect some significant effects, meaning that null findings, including those trending toward significance, may be significant with greater power.

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PACC slopes were more closely associated with contemporaneous neocortical tau slopes than with Aβ slopes, although these associations did not reach statistical significance within carriers, probably due to the small sample size.

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