The prognostic value of seminal anti-sperm antibodies screening in men prepared for ICSI: a call to change the current antibody-directed viewpoint of sperm autoimmunity testing.

Although the median value of fertilization rate was lower in patients with positive ASA compared with those with negative ASA, representing 56.3% and 66.7%, respectively, the difference did not reach statistical significance ( p = 0.091) ( Table 1 ).

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There was a highly significant difference between patients of both groups of negative and positive ASA regarding the median values of sperm count (mill/ml) 25 (IQR 12–34) versus 10 (IQR 5–20), ( p = 0.012), total motility 38 (IQR 20–50) versus 20 (IQR 10–30), ( p = 0.006), and morphology 90 (IQR 85–97) versus 98 (IQR 95–100), ( p = 0.011), as the three parameters were negatively affected by the existence of seminal ASA.

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