The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.

Nat Commun · 2021 · PMC7817666 · PMID 33473139

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a strong trendp = 0.06so close (0.05 < p ≤ 0.1)

As with the HBB donors, the majority of differentiated cells were CD19 + lymphoid and CD33 + myeloid cells, with a strong trend towards more genome editing within the CD33 + population (55.8 ± 12.0 vs. 22.3 ± 11.2; p = 0.06, two-tailed t-test) (Supplementary Fig. 4d, e ).

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